Home - Advanced Search - About - FAQ - Contact Us - Downloads
Mammalian Protein Subcellular Localization Database

  Quick search:       [ search protein IDs, descriptions, domain IDs, domain names and locations ] [ HELP ]
About the Project

The membrane organization and subcellular location of a protein can provide information about its functional role. Historically, these data have been difficult to produce on a large scale for higher eukaryotic organisms. However, recent advances in membrane organization prediction methods and high-throughput subcellular localization assays have made it possible to generate these datasets.
LOCATE is a curated, web-accessible database that houses data describing the membrane organization and subcellular localization of proteins from the FANTOM3 Isoform Protein Sequence set. Membrane organization is predicted by the high-throughput, computational pipeline MemO. The subcellular locations of selected proteins from this set were determined by a high-throughput, immunofluorescence-based assay and by manually reviewing over 1700 peer-reviewed publications. The results of the MemO pipeline and the subcellular localization methods are stored in the database with supporting information including a graphical depiction of the membrane organization juxtaposed with InterPro-predicted features and links to several external databases. The database is searchable by subcellular location, protein class, descriptive keyword, and sequence similarity. The data are retrievable in human- and machine-readable formats and in batch.
Representative Subcellular Localization Patterns

Copyright 2004, 2005, 2006, 2007 Institute of Molecular Bioscience, The University of Queensland and the ARC Centre in Bioinformatics
We gratefully acknowledge the support of the Australian Research Council.